Randomized clinical trial data suggest that 36% of patients who progressed on 1G/2G EGFR TKIs did not receive systemic second-line (2L) therapy [21], whereas real-world attrition rates from 1L to 2L in advanced/metastatic EGFRm NSCLC patients range from 10% to 62% [21,22,23,24]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.