In the occurrence and development of HCC, the inflammatory reaction is regulated by a variety of cytokines, such as interferon, tumor necrosis factor, interleukin, etc. The absolute values and ratios of neutrophils, lymphocytes, and monocytes, as the main inflammatory cells in the peripheral blood, can reflect the body’s inflammatory state to a certain extent, and the cytokines they secrete have pro-tumor and anti-tumor effects. This evidence concerns the gene TNF and neoplasm.