The most common toxicities included HFS (atezolizumab-cabozantinib: 7.9%; sorafenib: 8.2%), hypertension (atezolizumab–cabozantinib: 7.0%; sorafenib: 6.3%), AST elevation (atezolizumab–cabozantinib: 6.5%; sorafenib: 2.4%) and ALT elevation (atezolizumab–cabozantinib: 6.3%; sorafenib: 1.9%), all of which were less than 10% [30]. The gene discussed is GPT; the disease is hypertensive disorder.