The median serum levels of LC-SPIK, AFP, and PIVKA-II were significantly higher in patients with HCC compared to those without tumor (LC-SPIK: 24.3, 17.6–39.8 ng/mL vs. 11.7, 8.7–18.2 ng/mL; p < 0.001. Here, AFP is linked to hepatocellular carcinoma.