In a study by Li and colleagues, the depletion of YAP1 in endothelial cells resulted in an increase in exosomal MALAT1 released by these cells, which was transferred by exosomes into HCC cells to promote tumor cell invasion and metastasis by activating extracellular signal-regulated kinase 1/2 (ERK1/2) signaling [112]. Here, YAP1 is linked to hepatocellular carcinoma.