Secreted by tumor cells, exosomal lnc85 can bind and regulate miR-324-5p to promote the proliferation and migration of HCC cells [108], while exosomal LINC00161 can activate growth and metastasis-related signaling in HCC cells by targeting miR-590-3p and suppressing its downstream target ROCK2 [119]. Here, ROCK2 is linked to hepatocellular carcinoma.