LHX6 and hepatocellular carcinoma: In a study by You and colleagues, local hypoxia induced the production of exosomal miR-123f by HCC cells, and miR-123f, in turn, enhanced the proliferation, migration, invasion, and the EMT of HCC cells under low oxygen conditions by targeting LHX6 to inhibit the Wnt/β-catenin pathway [92].