Exosomal circRNA-SORE, upon transfer to HCC cells, can bind to YBX1 in the cytoplasm, block pre-mRNA processing factor 19 (PRP19)-mediated degradation to stabilize YBX1, and affect the expression of the downstream gene targets of YBX1 to transmit sorafenib resistance [144]. The gene discussed is PRPF19; the disease is hepatocellular carcinoma.