Fu et al. reported that multidrug-resistant cells (Bel/5-FU) activated the PI3K/AKT pathway to regulate angiogenesis and EMT by transferring exosomal miR-32-5p to HCC sensitive cells (Bel7402), thereby inducing the transformation of sensitive cells into drug-resistant cells [97]. Here, AKT1 is linked to hepatocellular carcinoma.