In a study by Li and colleagues, the depletion of YAP1 in endothelial cells resulted in an increase in exosomal MALAT1 released by these cells, which was transferred by exosomes into HCC cells to promote tumor cell invasion and metastasis by activating extracellular signal-regulated kinase 1/2 (ERK1/2) signaling [112]. The gene discussed is MAPK3; the disease is hepatocellular carcinoma.