Researchers have confirmed that lncRNAs derived from small extracellular vesicles (EV-lncRNAs) in serum, such as EV-DLEU2, EV-HOTTIP, EV-MALAT1, and EV-SNHG1, can distinguish HCC patients from non-HCC patients. Here, DLEU2 is linked to hepatocellular carcinoma.