In 2018, Sanchez-Vega et al. analyzed 33 cancer types including CRC and found high frequencies of variants in WNT, PI3K, TGFβ, RAS, HIPP, MYC, NOTCH, TP53, cell cycle, and NRF2 pathways, although the last two were less frequently mutated [22]. This evidence concerns the gene TGFB1 and cancer.