HSPA5 and cancer: To assess the role of Grp78 as a possible marker for targeting cancer cells and its role in the enhancement of RGD-core protein binding, Grp78-mCherry and tubulin-mCherry were overexpressed in HeLa cells and HepG2 cells and incubated with RGD-core protein for 2 h at a concentration of 100 μM.