Eight of the nine additional pathways were either predicted to continue the same opposing activity trend seen in earlier TPs relative to activity in lethal doses (apelin cardiomyocyte signaling, RhoGDI signaling, and signaling by Rho family GTPases), or were unique to lethal (the PCP pathway and corona pathogenesis pathway) or sublethal doses (cardiac hypertrophy signaling, natural killer cell signaling, and systemic lupus erythematosus in the B-cell signaling pathway). The gene discussed is APLN; the disease is systemic lupus erythematosus.