Our results are in accordance with a previous study, which reported that lncRNA MEG3 increases the transcriptional activity of the tumor suppressor p53 protein by interacting with its DNA binding domain (DBD), consequently influencing the expression of some of the genes regulated by p53 in hepatoma cells such as GADD45A, EGR1, SESN2 and TGFA [38]. This evidence concerns the gene EGR1 and hepatocellular carcinoma.