DNMT1 and hepatocellular carcinoma: On the contrary, the localization of truncated mature form of HCV core (C173) in the nucleus may induce HCC proliferation by different pathways, including the downregulation of tumor suppressor miRNA152, which targets oncoprotein wnt-1 [15], suppression of tumor suppressor P16 by upregulating DNA methyltransferase 1 (DNMT1), and DNMT3b that increases the hyper-methylation of P16’s promoter [16].