In this AD model, the Aβ peptide does not support CD59 and CD93, and does not protect neurons from inflammation; it does not support hippocampal synaptic plasticity (ATP11B); it does not support transport of Mg2+ to neurons (TRPM7 channel); and it does not control neuronal polyamine homeostasis (ATP13A3). Here, CD59 is linked to Alzheimer disease.