HSPG2 and Alzheimer disease: In the presented AD model, TF ZHX2 and GNG10 are supported, PTEN is upregulated and Gαo is complexed, and then the PI3K-Akt pathway is inhibited; RGS5 is suppressed, the PLC-IP3 pathway is supported and subsequently IP3 induces Ca2+ release from the ER.