PRRT2 and diabetes mellitus: According to various research hypotheses, the adverse effects of diabetes on the vascular system through the influence of hyperglycemia [10], especially on the endothelium, as possible targets include changes in cellular redox status, altered oxidized/reduced forms of nicotinamide adenine dinucleotide (NAD+/NADH) ratio [11]; dysregulation of tyrosine kinase proteins, whose activity is influenced by the redox state of their sulfhydryl groups [12]; protein kinase C (PKC) disorder [13]; and sorbitol accumulation [3].