ANGPT2 and glioblastoma: In addition to a distinct microenvironment, the GBM tumor has a hypoxic and necrotic core that aids in the cancer cell-induced blood vessel formation by increasing expression of pro-angiogenic VEGF, VEGFR2, and angiopoietin 2, which results in the disorganized network of blood vessels observed in GBM [243,248,249,250].