FGF2 and osteosarcoma: For instance, Zheng et al. developed a polyacrylic, acid-alginate-demineralized, bone matrix hybrid double-network hydrogel, which was shown to promote vascular endothelial growth factor (VEGF) synthesis and basic fibroblast growth factor (bFGF) and alkaline phosphatase activity of MG63 osteosarcoma cells to enhance bone regeneration [211].