TNF and Sepsis: This overwhelming immune response from the cytokines, including interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1b (IL-1b), macrophage inflammatory protein-1b, and tumor necrosis factor (TNF-a) leads to sequelae of sepsis via capillary leakage and organ failure [2,3].