Regarding the downstream regulation of FBL, in addition to participating in the regulation of ribosome synthesis, the latest research shows that FBL could directly modify specific types of mRNA by 2′-O methylation, thereby inhibiting its translation efficiency and achieving the regulation of specific gene expression, which suggests that the effect of FBL on the biological function of hepatocellular carcinoma may also play a role in this regard [30]. This evidence concerns the gene FBL and hepatocellular carcinoma.