Furthermore, in this study, HDAC3 was positively correlated with glycolipid levels, suggesting that Akkermansia muciniphila may be the main intestinal probiotic that improves metabolism in T2D.118 Based on previous evidence, FMT has been recognized as a therapeutic strategy that in combination with lifestyle can be potentially effective in the treatment of T2D.119 However, more evidence in humans needs to be generated, and we suggest that for future interventions, determining the baseline fecal microbiota composition may help predict treatment efficacy.112. This evidence concerns the gene HDAC3 and type 2 diabetes mellitus.