STAT3 and malignant colon neoplasm: Studies have shown [77, 78] that IL-6 cytokine produced by TAMs blocks the expression of tumor suppressor miR-204-5p by activating IL-6R/activator of transcription 3(STAT3) pathway in colon cancer cells, and miR-204-5p is a functional target that mediates TAMs-induced chemotherapy resistance in colon cancer.