TGFB1 and neoplasm: Based on extensive research, it has been proposed that TAMs in tumor microenvironment (TME) are multi-polarized as anti-inflammatory macrophages (M2 phenotype), which not only can promote tumor angiogenesis, growth, and the expression of various immunosuppressive cytokines but also has the potential to enhance the activities of IL-10, TGF-β, and hyperuricase-1 and stimulate the expression of cell surface markers [24, 25].