STAT3 and neoplasm: In addition, Yin et al. [79] showed that miR-155-5p in TAMs was frequently down-regulated, which led to the increase of the expression of the transcription factor CCAAT enhancer binding protein (C/EBP) β, while the transcription of C/EBPβ in TAMs could activate IL-6, and then IL-6 induced the chemotherapy resistance of tumor cells by activating the IL6R/STAT3/miR204-5P pathway.