In addition to malnutrition, the high levels of antibodies against thyroid antigens have been positively correlated with the clinical diagnosis of HT, especially for the thyroglobulin antibody (TGAb) against thyroid peroxidase (TPO) and the thyroid peroxidase antibody (TPOAb) against thyroglobulin (TG) (20–22). The gene discussed is TPO; the disease is nutritional deficiency disease.