Previous studies have shown that miR-135-5p preferentially binds to the G allele of rs3480 after upregulation, thus enhancing the attenuating effect of miR-135-5p on FNDC5 and reducing the FNDC5 mRNA levels, which results in a weakened regulatory effect of FNDC5 on metabolic diseases (37). The gene discussed is FNDC5; the disease is metabolic disease.