In APAs, this set of aldosterone-driver genes is complemented by somatic mutations in ATP1A1 and ATP2B3, which encode the ion pumps Na+/K+-ATPase and Ca2+-ATPase, and in genes that are targeted in multiple adrenal tumors such as CTNNB1 (β-catenin), and GNA11, GNAQ, and GNAS, encoding (guanine nucleotide-binding proteins), PRKACA (catalytic subunit of protein kinase A), and ARMC5 (a member of the armadillo/β-catenin-like repeat family) (Table 1). Here, PRKACA is linked to adrenal gland neoplasm.