Somatic mutations that constitutively activate WNT/β-catenin (CTNNB1), G-protein (GNAS, GNAQ, GNA11), and cAMP/protein kinase A (PKA) (GNAS, PRKACA) signaling can drive unrestrained cell proliferation and survival in diverse tumors, including adrenal tumors. Here, PRKACA is linked to adrenal gland neoplasm.