Finally, TRβ has also been identified as an inhibitor of tumor lymphangiogenesis and sentinel lymph node invasion in breast cancer by a mechanism involving N-CoR-mediated silencing of pro-metastatic and lymphangiogenic genes, such as VEGF-C and VEGF-D (111), which are targets of NF-kB signaling pathway (121). The gene discussed is THRB; the disease is breast cancer.