Indeed,the association between proteinuria and glomerular disease is well known, butnotable persistent ischemic and/or toxic tubular injury can lead to proximal tubularnecrosis and local inflammation, reducing the capacity to reabsorb filtered albumin,while increasing the overall protein loss by the tubular degeneration/regeneration process.18 This sub-nephrotic protein loss was observed for none of the functional AKIcases (hypovolemia, CRS, HRS), where the tubular functions are normally preserved(Supplemental Table S2). The gene discussed is ALB; the disease is glomerular disorder.