When all study participants were considered, the SPISE index (r=-0.049, p=0.528) showed no significant association while three groups were taken into account separately, sclerostin revealed a significant (r=0.269, p=0.043) correlation with SPISE index in the prediabetes group but not in the newly diagnosed T2D group (r=-0.044, p=0.745) (Figure 5). This evidence concerns the gene SOST and type 2 diabetes mellitus.