KEAP1 and lung adenocarcinoma: Among the most frequently mutated genes in lung adenocarcinoma patients are the oncogenes Kirsten rat sarcoma viral oncogene homolog (KRAS) (32%) and epidermal growth factor receptor (EGFR) (27%), as well as the tumor suppressor genes TP53 (46%), Kelch-like ECH-associated protein 1 (KEAP1) (19%), serine/threonine kinase 11 (STK11) (17%), and neurofibromin 1 (NF1) (11%).