Finally, it has been reported that kinesin-5 and kinesin-14 double-inhibition can restore up to 20-40% spindle bipolarity in cancer cells CFPAC1 (Mountain et al., 1999) and HeLa (Tsui et al., 2009, Watts et al., 2013), indicating that HSET can oppose the activity of Eg5. This evidence concerns the gene KIF11 and cancer.