TNF and chronic atrophic gastritis: In conclusion, based on the results of network pharmacology, it was shown that Rhizoma phragmitis and Rhizoma curcumae would regulate MAPK, TNF signaling pathway, and inflammatory factor target genes in rats with chronic atrophic gastritis, and this therapeutic regimen is highly efficient and can improve gastric function, relieve the inflammatory response, and significantly reduce the number and duration of reflux in rats with chronic atrophic gastritis, which is a safe and effective therapeutic modality.