The underlying mechanism is still currently unclear, probably because Tau protein and amyloid-β are selectively deposited in the hippocampal cortex of patients during early onset of AD (Braak and Braak, 1997), resulting in a coherent alteration in the local activity of brain function, which is consistent with previous Regional Homogeneity (ReHo) findings in AD and aMCI patients (Zang et al., 2004; Cha et al., 2015; Wang et al., 2015). The gene discussed is MAPT; the disease is Alzheimer disease.