AGER and Alzheimer disease: Plasma sLRP1 levels and Aβ binding to sLRP1 are significantly reduced due to increased levels of oxidized sLRP1, which does not bind Aβ, resulting in an increase in free Aβ levels in plasma to return to the brain via the receptor for advanced glycation end products (RAGE) in patients with AD (Deane et al., 2003; Sagare et al., 2007, 2011).