Previous studies have shown that the plasma CyPA level is a new biomarker for the diagnosis of coronary artery disease (CAD) and renal disease progression and is used as a prognostic factor in patients with ruptured intracranial aneurysms (Satoh et al., 2013; Ramachandran et al., 2014; Kao et al., 2015; El-Ebidi et al., 2020; Rath et al., 2020). This evidence concerns the gene PPIA and coronary artery disorder.