XK and influenza: Interestingly, our results revealed that immunization of EΔM-tM2e- and EΔM-HM2e-VLPs elicited robust production of influenza M2e-specific antibodies, while EΔM-HM2e-VLPs also mediated significantly higher anti-HA antibody than HA/NA/M2-VLPs on day 63 (Figures 2C,D).