SYK and vasculitis: Anzai et al. found that CAWS mediates IL-1β and NLRP3 inflammasome activation through the Dectin-2/Syk/JNK/NF-κB pathway and the Dectin-2/Syk/JNK/mitochondrial Reactive oxygen species (mtROS) pathway, which both participate in KD vasculitis (48).