S1PR1 and myocardial infarction: Mechanically, S1pr1 signaling activates ERK signaling pathway in LECs, and boosts CCL2 expressions, resulting in the recruitment of infiltrating macrophages in myocardium toward lymphatic endothelium and an enhancement in macrophage clearance from ischemic myocardium via afferent cardiac lymphatics, and consequently dampens post-MI inflammation and improves cardiac functions (Figure 7).