SLC7A11 and fibrosarcoma: Dixon et al. (3) showed that the selectively RAS-lethal small molecule erastin not only modulated the mitochondrial voltage-dependent anion channel (VDAC), but also inhibited the function of SLC7A11, an important subunit of the cystine/glutamate reverse transporter system Xc– (xCT), reducing intracellular glutathione (GSH) synthesis, further increasing the accumulation of iron-dependent lipid peroxide and inducing the death of RAS mutant fibrosarcoma cell lines.