In contrast to AMKL in pediatric patients with Down syndrome (DS-AMKL), AMKL in pediatric patients without DS (non-DS-AMKL) is much rarer and more heterogeneous, a significant proportion of whom carry chimeric oncogenes including RBM15-MKL1, CBFA2T3-GLIS2, NUP98-KDM5A, and MLL gene rearrangements. The gene discussed is KMT2A; the disease is Dravet syndrome.