Acute megakaryoblastic leukemia [AMKL or AML-M7 in the French–American–British (FAB) classification] (1) is a subtype of acute myeloid leukemia (AML) characterized by abnormal megakaryoblasts that express platelet-specific surface glycoprotein, including CD41, CD42, and CD61. This evidence concerns the gene ITGB3 and acute megakaryoblastic leukemia.