ETV6 and chronic myelogenous leukemia, BCR-ABL1 positive: Further studies are warranted to elucidate the mechanisms of ETV6 mutations and their role in the processes of differentiation and proliferation in the early progression of leukemic alteration and whether they may also be relevant in the induction of chromosomal variability, finally prompting the development of clones with other molecular mutations and leading to myeloid blast transformation in CML patients.