ITGB1 and synovial sarcoma: Interestingly, the blocking of fibrotic activity in skin SS myofibroblasts with a YAP inhibitor, verteporfin, reduced the expression of ITGA11, ITGB1, PDGFRB, COL1A1, and many other ECM-associated genes (56), further reinforcing the view that α11 and PDGFRβ are concomitantly regulated and form a signaling hub that promotes myofibroblast activation in fibrotic tissues.