The α11 expression was most prominent in the desmoplastic stroma of malignant high-grade human cSCCs, where the intense, tangle-like α11 signals resembled the staining patterns that have previously been reported for this integrin subunit in human HNSCC (15), as well as in human breast, lung and pancreatic adenocarcinomas (12, 16, 17). Here, IGKV3D-20 is linked to head and neck squamous cell carcinoma.