Our current immunostainings of tumor tissues and FACS analysis, together with the previously published data on α11 in fibroblasts, reinforce the perception that integrin α11β1 signaling plays an active role in mediating the differentiation of skin fibroblasts into myofibroblasts and CAFs but does not play a significant role in the differentiation of SVF progenitors into subcutaneous adipocytes. This evidence concerns the gene IGKV3D-20 and neoplasm.