To advance our understanding of integrin α11β1 in cSCC, we analyzed the expression of the α11 subunit in human cSCC samples and in benign and premalignant human skin lesions via immunohistochemistry (IHC) and subjected mice deficient in the α11 subunit to the broadly used murine model of skin cancer, the multistep chemical skin carcinogenesis protocol involving 7,12-dimethylbenz[α]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) treatments (24). The gene discussed is IGKV3D-20; the disease is skin cancer.