In this research, samples of lung adenocarcinoma were interrogated with cuproptosis-related genes, among which high expression of DLD, DLAT, PHDA1, PHDB, and CDKN2A were correlated with poor OS, while high expression of MTF1 was correlated with longer OS compared with the MTF1 low expression. Here, P4HB is linked to lung adenocarcinoma.