All six genes were expressed in both LUAD subgroups, with a significant differential expression of DLD, PDHA1, CDKN2A, DLAT, and MTF1 in subgroup B. Since this five-gene model showed significant correlations with poor clinical outcomes in lung adenocarcinoma, we name it cupLA panel for further analysis. This evidence concerns the gene CDKN2A and lung adenocarcinoma.