The results showed that RBM15 (HR = 0.69, 95% CI = 0.52–0.92), FTO (HR = 1.46, 95% CI = 1.09–1.96), MSI2 (HR = 0.75, 95% CI = 0.58–0.97) and ZC3H7B (HR = 0.70, 95% CI = 0.53–0.93) was associated with prognosis in gastric cancer patients and the RiskSscore model was established. Here, FTO is linked to gastric cancer.