Polyamine may induce tumor cell proliferation and metastasis by up-regulating the expression of ornithine decarboxylase, spermidine, and spermine acetyltransferase, and Akt1.Nitric oxide can interfere with T cell function by inducing T cell apoptosis.Arginine depletion in GBM can induce excessive autophagy, which will be toxic to tumor cells and may induce apoptosis. The gene discussed is AKT1; the disease is glioblastoma.