AHR and central nervous system cancer: AHR signaling pathway may modify metabolic pathways associated with amino acid, which inhibits the function of immune cells such as glioma-associated macrophages, T cells, antigen-presenting cells, astrocytes, and microglia, resulting in inhibitory changes in the immune microenvironment during the occurrence and development of gliomas, and promoting glioma invasion and migration (60, 62).