The reasons were as follows: 1) The high BRAF mutation rate of GBM in our study may be resulted from a high proportion of E-GBMs whose BRAF mutation rate was more than 50%; 2) Differences in human species may cause the bias about the BRAF mutated proportion in GBM; 3) Only 44 cases and 2 departments could not sufficiently reflect the truth. Here, BRAF is linked to glioblastoma.