Among the DH cases, in one family, two individuals (sisters) carried three germline pathogenic variants in BC-risk genes (F02114), comprising BRCA1 c.5266dup (p.Gln1756fs), TP53 c.1010G>A (p.Arg337His), and PALB2 c.3271C>T (p.Gln1091Ter). Both sisters were affected by BC at a young age (32 and 40 years). The gene discussed is BRCA1; the disease is breast cancer.