C1QTNF8 is predicted to be part of a collagen trimmering and, in humans, it is considered a paralog of C1QTNF6. A DNA methylation analysis found that the C1QTNF8 was differentially methylated in osteoarthritis (OA) subchondral bone (Jeffries et al., 2016), while its paralogous is a marker for OA in mouse, acting in host defense, inflammation and glucose metabolism (Murayama et al., 2014, 2015). This evidence concerns the gene C1QTNF6 and osteoarthritis.