MAP2K4 and neoplasm: It has been reported that quercetin can bind to kinases such as PI3K-Akt/PKB, SEK1, and MAPK to induce tumor cell cycle arrest and inhibit growth and metastasis, antioxidant replication, and angiogenesis by participating in the induction and expression of phosphorylation of key intracellular targets (Darband et al., 2018).