We found an important number of patients using diuretics (n = 125), ACE inhibitors and ARB blockers (n = 163), and NSAIDs (n = 43) who had ARF (Table 2) The most frequent comorbidities of the patients with ARF were hypertension, cardiac disorders, depression and anxiety, hyperlipidemia, and pain. The gene discussed is ACE; the disease is hypertensive disorder.