We found an important number of patients using diuretics (n = 125), ACE inhibitors and ARB blockers (n = 163), and NSAIDs (n = 43) who had ARF (Table 2) The most frequent comorbidities of the patients with ARF were hypertension, cardiac disorders, depression and anxiety, hyperlipidemia, and pain. This evidence concerns the gene ACE and major depressive disorder.