The JADER database study (Katsuhara and Ogawa, 2020) did not find a significant association between SGLT2 inhibitors and ARF, but 1) the database is smaller (only 126 ARF cases reported to SGLT2) and also 2) they used ARF broad definition and included 50 PTs, which may have affected their ROR. This evidence concerns the gene SLC5A2 and acute kidney injury.