Tissue inhibitor of metalloproteinase-2 (TIMP-2) and Smad7 expression—an inhibitory regulator of TGF-β (Ma et al., 2018)—were increased in the rats (Zhang et al., 2021a), suggestive of a strong suppressive effect of the drug on myocardial fibrosis production. Here, TIMP2 is linked to Myocardial fibrosis.