Sacubitril/valsartan (60 mg/kg/day for 4 weeks) administration in mice attenuated doxorubicin-induced dilated cardiomyopathy, observed by a curb on apoptosis that preserved mitochondrial function via the dynamin-related protein 1 (Drp1)-mediated pathway (Xia et al., 2017; Yeh et al., 2021a) (Figure 3). The gene discussed is DNM1L; the disease is dilated cardiomyopathy.