SLC5A2 and heart failure: However, two other clinical trials reported no significant combinatory effects of SGLT2 inhibitors (dapagliflozin or empagliflozin) and sacubitril/valsartan in patients with heart failure, even though the effect magnitudes were numerically bigger than in those receiving SGLT2 inhibitor alone (Solomon et al., 2020; Packer et al., 2021).