Histologically, oral administration of 68 mg/kg/day sacubitril/valsartan for 5 weeks in LAD coronary artery ligation-induced MI rats significantly decreased myocardial interstitial fibrosis accompanied by reduced connective tissue growth factor (CTGF) expression, a known mediator of TGF-β activity during fibrosis (Pfau et al., 2019). Here, CCN2 is linked to myocardial infarction.