Peng et al. (2020) demonstrated that post-treatment with sacubitril/valsartan (20 mg/kg/day) for 4 weeks in mice with pressure overload-induced heart failure distinctly reversed the downregulation of manganese superoxide dismutase (MnSOD), sirtuin-3 (SIRT3), and phosphorylated 5' adenosine monophosphate-activated protein kinase (p-AMPK) expression. This evidence concerns the gene SIRT3 and heart failure.