The drug is tolerated well and linked to a low incidence of angioedema due to a smaller increase in bradykinin in patients as compared with ACE inhibitors such as enalapril (Desai et al., 2015; McCormack, 2016; Yandrapalli et al., 2017; Myhre et al., 2019; Tanase et al., 2019). The gene discussed is ACE; the disease is angioedema.