NPPB and cardiac hypertrophy: The results showed that the expression of cardiac hypertrophy marker gene BNP was increased in si-NC+PE group compared with si-NC group, and treatment with si-mmu-Hecw2_0009 decreased mRNA expression of BNP in si-mmu-Hecw2_0009+PE group compared with si-NC+PE group (Figures 9A,B).