AKT1 and diabetic kidney disease: Yiqi Jiedu Huayu Decoction can promote autophagy in streptozotocin (STZ)-induced diabetes mellitus rats by upregulating the expression of autophagy-related proteins, regulating the activity of the PI3K/Akt and AMPK pathways, inhibiting the mTOR pathway, and promoting autophagy of STZ-induced diabetic nephropathy (Xuan et al., 2021).