AKT1 and cancer: As for KEGG pathway analysis, the significant pathways associated with breast cancer were EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, hemical carcinogenesis-receptor activation, JAK-STAT signaling pathway, and MicroRNAs in cancer (Figure 4).