ADA and neoplasm: In addition to its enhanced ability to inhibit proliferation and promote tumor cell apoptosis, ADA may offer numerous advantages over conventional retinoic acid derivatives in vivo, such as increased stability, more prolonged comedolytic action, enhanced anti-inflammatory activity, and a favorable safety profile (Ocker et al., 2003; Shi et al., 2015; Ghosalkar et al., 2018; Rusu et al., 2020; Sofi et al., 2022b).