PDHA1 and hereditary pheochromocytoma-paraganglioma: In contrast, PDHA1 was significantly downregulated in six tumors, namely, breast invasive carcinoma (BRCA), glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), pheochromocytoma and paraganglioma (PCPG), and thyroid carcinoma (THCA).