Sun et al. (2019) demonstrated that IL-6 was increased in the supernatant of isolated CAFs, which could promote BRCA cell proliferation. In recent years, emerging studies have proved the well-established role of B cells in shaping antitumor immunity. Song et al. (2022) found that B-cell marker genes could effectively indicate the patients’ survival and provide targets for immunotherapy in lung cancer. The gene discussed is IL6; the disease is lung carcinoma.