Upon activation via its ligand, stem cell factor (SCF), c-KIT can activate several signaling pathways and thereby play a regulatory role in cardiovascular diseases, including vascular diseases (Kim et al., 2014; Hernandez et al., 2019), cardioprotection (Ebeid et al., 2020), and cardiac stem cell migration (Kuang et al., 2008). This evidence concerns the gene KITLG and cardiovascular disorder.