In atherosclerosis, which shares similar pathological features with CAVD (Kostyunin et al., 2020), DHM has been shown to increase endothelial nitric oxide production in apolipoprotein E-deficient mice (ApoE−/−) (Yang et al., 2020) and protect human umbilical vein endothelial cells from oxidative damage (Zhang et al., 2019). This evidence concerns the gene APOE and atherosclerosis.