Compared with matched normal tissues, the DNA methylation of PDIA5 was upregulated in LIHC, LUAD, BLCA, kidney renal papillary cell carcinoma (KIRP), thyroid carcinoma (THCA), and esophageal carcinoma (ESCA), whereas downregulated in KIRC, lung squamous cell carcinoma (LUSC), PRAD, HNSC, COAD and BRCA (Figure S1C). The gene discussed is PDIA5; the disease is squamous cell lung carcinoma.