SHPK and cancer: PDIA5 was involved in various human diseases, especially cancers, as shown in Figure S1A, and the interactions between PDIA5 and TXNDC12, PLRG1, PPP1R2, POLR2G, INTS8, SHPK, KIAA0391, HYOU1, as well as XBP1 were also depicted (Figure S1B).