More significantly, the expression level of PDIA5 showed positive correlations with the T cells and macrophages-related immune pathways in BLCA, COAD, GBM, KIRC, KIRP, LGG, and rectum adenocarcinoma (READ), and negative correlations in CESC, LUSC, PRAD, and THCA. The gene discussed is PDIA5; the disease is rectum adenocarcinoma.