Compared with matched normal tissues, the DNA methylation of PDIA5 was upregulated in LIHC, LUAD, BLCA, kidney renal papillary cell carcinoma (KIRP), thyroid carcinoma (THCA), and esophageal carcinoma (ESCA), whereas downregulated in KIRC, lung squamous cell carcinoma (LUSC), PRAD, HNSC, COAD and BRCA (Figure S1C). This evidence concerns the gene PDIA5 and carcinoma of esophagus.